R patient’s condition. He was treated with topical retinoic acid and activated vitamin D3 ointment for 3 months every, however the lesions remained unchanged.Nevus comedonicus is definitely an uncommon skin abnormality characterized by an aggregation of dilated follicular oriCorresponding author: Takamichi Ito, MD [email protected] Received 2013 February 25 Accepted 2013 MarchDISCUSSION Since the very first description by Kofmann,1 about 200 situations of nevus comedonicus have been reported, although bilateral nevus comedonicus and nevus comedonicusT. Ito et al.syndrome have already been reported only sporadically. Our patient’s case is of interest in that it showed bilaterally disseminated comedolike lesions with a variety of systemic complications. The skin lesions have been clinically and histopathologically compatible with bilateral nevus comedonicus. To our expertise, bilateral nevus comedonicus accompanied by systemic complications as discovered in our patient has not been reported in the English literature. To create a diagnosis of “bilateral nevus comedonicus syndrome”, we need to rule out other ailments showing many comedo- Fig. 1. Many skin-colored papules and comedo-like lesions on the neck. like lesions or skin-colored papules such as acne vulgaris, chloroacne, Favre-Racouchot disease, familial dyskeratotic comedones, idiopathic disseminated comedones, disseminated congenital comedones, multiple congenital comedones, verruca vulgaris and Apert syndrome. Acne vulgaris is really a prevalent illness that should be regarded as a differential diagnosis. The diagnosis of acne vulgaris is usually created from the clinical locating of a mixture of acne lesions for instance comedones, papules, pustules, nodules and hypertrophic scars.Formula of 1312941-98-2 four Fig. two. Dilated and invaginated follicular structures filled with lamellar keratin (heIt is observed primarily in adolescents and usu- matoxylin and eosin staining). Bar = 1000 . ally lacks systemic complications. For that reason, acne vulgaris isn’t the right diagnosis for our patient.Benzene-1,2-dithiol Price Chloracne, caused by halogenated chemical case report of this disease so far.PMID:24282960 Disseminated congenicompounds, is a well-known dermatosis consisting of tal comedones was described by Galvan within a 3-monthdiffuse acneiform lesions with diffuse grayish skin pigold boy who had congenital and extensive skin comedomentation,five but our patient had no history of exposure nes confined towards the upper half of your physique.9 Our case can to halogenated chemical compounds or other acnegenic be differentiated from this illness because of the distrisubstances. Favre-Racouchot illness is a cutaneous disbution and onset age of comedones. A number of congenital 6 order with grouped comedones in sun-damaged skin. comedones is usually a not too long ago described situation displaying congenital bilateral comedones and a few systemic The lesions are usually symmetrically distributed withcomplications.10 Our case does not match with this disease out building inflammation, however the places of this illness are confined to sun-exposure areas. Familial dysbecause of your onset of comedones. Verruca vulgaris keratotic comedones is usually a rare abnormality characterized from time to time occurs as many skin-colored lesions,11 by symmetrically scattered comedo-like hyperkeratotic but this illness may be clearly discriminated from ours papules.7 It really is inherited as an autosomal dominant condihistopathologically. Apert syndrome, characterized by craniosynostosis, mid-facial malformations, symmetrition, which can distinguish it from our case. Idi.
