Age in years Median weight (kg) Continent of birth N ( ) Europe French West Indies Africa Other people Preceding history of malaria HIV constructive Pretravel take a look at Travel clinic Family physician Unknown Chemoprophylaxis Chloroquine Chloroquineproguanil Mefloquine Atovaquoneproguanil Doxycycline Proguanil Unknown Compliance to chemoprophylaxis Nonmedical prophylaxis Airconditionning only Insecticides only Unimpregnated bed net only Impregnated bed net only Repellents only Impregnated bed net and repellents No prophylaxis Unknown Place of contamination West Africa Central Africa Madagascar and Comoros East Africa Asia Angola and South Africa Ha i and French Guyana 342 (61.eight) 148 (26.8) 51 (9.2) five (0.9) three (0.five) 2 (0.four) two (0.4) 1 (0.2) 5 (0.9) 11 (two) 23 (four.1) 23 (four.1) 12 (2.2) 400 (72.four) 78 (14.1) 51 (9.two) 4 (0.7) 490 (88.six) eight (1.five) 264/492 (53.7) 21/478 (4.four) 267 (48.three) 74 (27.7) 113 (42.3) 80 (30.0) 222 (40.1) 30 (13.5) 142 (64) 24 (10.8) 1 (0.four) 13 (5.9) ten (4.5) 2 (0.9) 50/222 (22.five) 1.9 38.3 (129) 74 (4009)Table 1 Primary characteristics of 553 individuals treated with atovaquoneproguanil for imported uncomplicated malaria (Continued)Form of travel Backpackers Hostel Visiting buddies and relatives Unknown: variety of individuals with accessible data.33 (six.0) 11 (2.0) 431 (77.9) 78 (14.1)Table two Admission variables and outcome in 553 sufferers treated with atovaquoneproguanil for imported uncomplicated malariaTemperature at diagnosis N ( ) 37.7C37.839C39.140C40CSymptoms at diagnosis Headache Nausea/vomiting Diarrhoea Myalgia Abdominal pain Arthralgia Compliance to followup Day three Day 7 Day 30 Hospitalization Hospitalized at diagnosis Nonetheless hospitalized at day three Nonetheless hospitalized at day 7 Nonetheless hospitalized at day 30 Fever clearance (apyrexia) Day three Day 7 Day 30 Parasitological clearance (negative parasitaemia) Day 3 Day 7 Day: number of patients with readily available data.175 (31.6) 208 (37.six) 104 (18.8) 19 (3.four)256 (46.3) 156 (28.two) 102 (18.5) 81 (14.7) 32 (five.eight) 20 (three.six)469 (84.1) 364 (65.eight) 265 (47.9)191 (34.5) 124 (22.4) 15 (two.7) 2 (0.3)403/425 (94.8) 323/323 (100) 227/227 (100)292/425 (68.7) 331/331 (100) 215/217 (99.1)Cordel et al. Malaria Journal 2013, 12:399 http://www.malariajournal.com/content/12/1/Page 5 ofTable 3 Biology information in 553 individuals treated with atovaquoneproguanil for imported uncomplicated malariaDiagnosis Haemoglobin (g/dL) 8 8.Price of 856563-00-3 110 10.61881-19-4 Price 112 12 Platelets count (per mm ) 20,000 20,00150,000 50,001100,000 100,001150,000 150,000 Leucocytosis White blood cells four,500 per mm3 White blood cells four,500 per mm Cytolysis ALAT 1 N ALAT 1.PMID:23563799 12 N ALAT two.13 N ALAT 3 N Creatinine (mol/L) 120 121140 140 507 (91.7) 36 (six.five) ten (1.eight) 431 (91.9) 25 (five.3) 13 (two.8) 349 (95.9) 8 (2.2) 7 (1.9) four (1.five) 253 (95.5) eight (3.0) 385 (69.6) 135 (24.4) 27 (four.9) 6 (1.1) 287 (61.two) 140 (29.9) 24 (5.1) 18 (three.eight) 201 (55.two) 117 (32.1) 20 (five.five) 26 (7.1) 219 (82.6) 44 (16.six) 2 (0.eight)3Day three N ( ) 16 (3.four) 55 (11,7) 162 (34.6) 236 (50.3)Day 7 N ( ) 4 (1.1) 48 (13.2) 126 (34.6) 186 (51,1)Day 30 N ( ) 0 17 (6.4) 73 (27.six) 175 (66.0)N ( ) 11 (1.9) 28 (5.1) 136 (24.6) 378 (68.4)eight (1.four) 43 (7.eight) 173(31.three) 160 (28.9) 169 (30.six)4 (0.8) 14 (three.0) 102 (21.8) 121 (25.eight) 228 (48.6)0 1 (0.3) 1 (0.3) six (1.6) 356 (97.eight)0 0 0 7 (two,six) 258 (97,4)218 (39.four) 335 (60.6)242 (51.6) 227 (48.four)55 (15.1) 309 (84.9)48 (18.1) 217 (81.9)typical (150,000/mm3) in 30.six of instances and significantly less than 20,000/mm3 in eight sufferers (1.five ). At day 7, 99.four of sufferers had additional than 100,000 platelets/mm3.Outcomeanswered was classified as e.
